Research Associate II- Imaging

Fusion Pharmaceuticals
Fusion Pharmaceuticals
Job Functions:
Other Engineering, Operations
Employment Types:
Full-time
Locations:
Hamilton, ON, Canada
Compensation:
USD per year
Posted on:
09/21/2022

Fusion Pharmaceuticals is a clinical-stage oncology company focused on developing next-generation radiopharmaceuticals as precision medicines. Employing a proprietary Fast-Clear™ linker technology, and leveraging the Company’s actinium supply and manufacturing expertise, Fusion connects alpha particle emitting isotopes to various targeting molecules in order to selectively deliver the alpha emitting payloads to tumors. Fusion's lead program, FPI-1434 targeting insulin-like growth factor 1 receptor, is currently in a Phase 1 clinical trial. The pipeline includes FPI-1966 targeting the fibroblast growth factor receptor 3 (FGFR3) and FPI-2059, a small molecule acquired from Ipsen, targeting neurotensin receptor 1 (NTSR1). In addition to a robust proprietary pipeline, Fusion has a collaboration with AstraZeneca to jointly develop up to three novel targeted alpha therapies (TATs), the first of which is currently in IND enabling studies, and explore up to five combination programs between Fusion's TATs and AstraZeneca's DNA Damage Repair Inhibitors (DDRis) and immuno-oncology agents. Fusion also recently entered into a collaboration with Merck to evaluate FPI-1434 in combination with Merck's KEYTRUDA® (pembrolizumab) in patients with solid tumors expressing IGF-1R.

Research Associate – Imaging

Fusion Pharmaceutical is seeking a candidate for Research Associate, Imaging who will provide technical expertise in the execution of imaging methods and image analysis applied to pre-clinical studies across therapeutic areas. The candidate will work collaboratively with internal research teams to integrate and support the application of imaging towards targeted alpha-particle therapeutic (TAT) development. This position is based at Fusion’s laboratories in Hamilton, Ontario, Canada.

Responsibilities:

  • Reporting to the Imaging Team leader;  develop Fusion’s internal preclinical imaging capabilities and contribute towards incorporation of nuclear imaging modalities into Fusion’s existing experimental workflow
  • As part of Fusion’s Discovery team; work with radiochemistry, biology and non-clinical research departments to develop imaging-based techniques to expand or enhance existing programs and capabilities
  • Design and conduct imaging-based biodistribution studies of radiopharmaceuticals in rodent models of cancer (or other disease indications of interest).  Perform image processing and analysis to generate quantitative and qualitative imaging data
  • Maintain, calibrate, and operate state of the art PET/SPECT/CT/Optical imaging equipment
  • Produce high quality and well documented data with strong attention to detail
  • Contribute to internal project teams through the setting and achievement of scientific goals, communication of results, and solving multifaceted scientific challenges
  • Other duties as required

Qualifications:

  • MSc or an experienced BSc (at least 3-years of relevant experience as described below)
  • Experience with design and conduct of in vivo imaging studies including animal handling, compound administration (various routes).
  • Experience with software image reconstruction and analysis including quantification
  • Experience with nuclear (PET/SPECT/CT) imaging methods and protocols is a strong preference.  Candidates with extensive experience in non-nuclear imaging modalities may also be considered.
  • Experience with _in vivo _xenograft models in rodents preferred, including experience with cell-culture and tumour implantation.
  • Ability to adapt to, perform, and develop unfamiliar methods in a rapidly evolving research environment
  • Verbal and written proficiency in English
  • Ability to work effectively in a multi-disciplinary team and communicate with colleagues at all levels
  • Experience with the safe handling of radioactive and potentially biohazardous materials

Fusion requires all employees to be current with their COVID vaccination requirements.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.