Scientist II, Biology

Fusion Pharmaceuticals, a member of the AstraZeneca Group, is a clinical-stage oncology company focused on developing next-generation radioconjugates (RCs) as precision medicines. Fusion connects alpha particle emitting isotopes to various targeting molecules to selectively deliver the alpha emitting payloads to tumors. Fusion’s clinical portfolio includes: FPI-2265 targeting prostate specific membrane antigen (PSMA) for metastatic castration resistant prostate cancer currently in a Phase 2 trial; FPI-1434 targeting insulin-like growth factor 1 receptor currently in a Phase 1 trial; FPI-2068, a bispecific IgG-based EGFR-cMET targeted radioconjugate currently in a Phase 1 trial. In addition, Fusion is pursuing combination programs between RCs and DNA Damage Response Inhibitors (DDRis) and immune-oncology agents. Fusion has a fully operational Good Manufacturing Practice (GMP) compliant state-of-the-art radiopharmaceutical manufacturing facility to meet supply demand for Fusion's growing pipeline of RCs.

Fusion is seeking outstanding applicants for a Scientist II, Biology, to contribute to ongoing or new initiatives. This position is lab-based, and located in Hamilton, Ontario, Canada.

Responsibilities

• Scientist II, Biology will be expected to spend time in the lab to execute experiments as needed
• Lead drug discovery projects by setting objectives, delivering and communicating results according to timelines
• Contribute to drug development through scientific input and support go/no-go decision-making for projects
• Adapt or develop, validate, and perform bioassays in a rapidly evolving research environment
• Identify and develop new techniques and molecular targets to expand or enhance existing programs
• Design and conduct therapeutic efficacy and biodistribution studies on radiopharmaceuticals in rodent models of cancer (or other disease indications of interest)
• Produce high quality and well documented data with strong attention to detail
• Assist in data preparation for IND and patent submissions
• Analyze, interpret, and present experimental results at both internal and external meetings
• Lead research associates and technicians assigned to their project/program and supervise their work

Qualifications:

• Ph.D. in Molecular/Cell Biology, Biology, Biochemistry or related field with 0-3 years of related experience. MSc with 6+ years of industry experience in similar roles will be considered.
• Direct experience in cancer biology is required.
• Experience with development and technical validation of in vitro bioassays; knowledge of biologic screening assays is an asset.
• Experience with development and validation of in vivo cancer models in small rodents
• Skilled in general biochemical (e.g., protein quantification, ELISA, SDS-PAGE and immunoblotting, UV/VIS spectroscopy) and cell biological methods (e.g., Cell culture, flow cytometry, immunohistochemistry)
• Prior experience and interactions with external contract research organizations (CROs) is preferred but not required
• Ability to adapt to, perform, and develop unfamiliar methods in a rapidly evolving research environment
• Verbal and written proficiency in English
• Ability to work effectively in a multi-disciplinary team and communicate with colleagues at all levels
• Experience with Good Laboratory Practice (GLP) guidelines to ensure compliance with regulatory standards.
• Experience with the safe handling of radioactive and biohazardous materials is an asset.
• A strong publication record is preferred.

Fusion Pharmaceuticals is an equal opportunity employer that is committed to inclusive, barrier-free recruitment and selection processes, if contacted for an interview, please advise Human Resources if you require accommodation.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.