Fusion Pharmaceuticals, a member of the AstraZeneca Group, is a clinical-stage oncology company focused on developing next-generation radioconjugates (RCs) as precision medicines. Fusion connects alpha particle emitting isotopes to various targeting molecules to selectively deliver the alpha emitting payloads to tumors. Fusion’s clinical portfolio includes: FPI-2265 targeting prostate specific membrane antigen (PSMA) for metastatic castration resistant prostate cancer currently in a Phase 2 trial; FPI-1434 targeting insulin-like growth factor 1 receptor currently in a Phase 1 trial; FPI-2059, a small molecule targeting neurotensin receptor 1 (NTSR1), currently in a Phase 1 trial; and FPI-2068, a bispecific IgG-based EGFR-cMET targeted radioconjugate currently in a Phase 1 trial. In addition, Fusion is pursuing combination programs between RCs and DNA Damage Response Inhibitors (DDRis) and immune-oncology agents. Fusion has a fully operational Good Manufacturing Practice (GMP) compliant state-of-the-art radiopharmaceutical manufacturing facility to meet supply demand for Fusion's growing pipeline of RCs.

The Senior Director, Biology position is located in Hamilton, Ontario, Canada and will report to the Chief Scientific Officer.

Responsibilities:

• Oversees programs from target identification through translational research as programs progress from drug discovery to clinical development

• Oversees ex vivo and in vivo research to generate datasets for nomination of lead candidates

• Oversees workstreams to identify best patient populations for each program

• Explores and defines drug mechanism of action, drug combination partners and biomarkers for each program

• Manages external research projects with vendors and CROs

• Collaborates closely with multi-disciplinary team members across the entire organization

• Provides hands-on supervision, leadership, and mentoring of research associates and junior scientists

• Establishes strong scientific excellence and fostering an open culture of challenging assumptions, open scientific exchange, and deep scientific rigor

• Manages weekly CSO reports from Discovery

• Has shared responsibility with CSO for departmental budgets

Qualifications

• Ph.D. or M.Sc. with 7+ years of post-graduate experience (Biochemistry, Biology, Molecular/Cell Biology)

• Experience in the pharmaceutical industry with emphasis on drug discovery or translational research

• Experience in managing a mid-sized research team and developing people is required

• Experience with development and technical validation of in vitro bioassays; knowledge of screening assays for biologics or small molecule

• Experience with general biochemical (e.g., protein quantification, ELISA, SDS-PAGE and immunoblotting, UV/VIS spectroscopy) and cell biological methods (e.g., flow cytometry, immunohistochemistry)

• Ability to develop drug discovery and translational strategies is a must

• Ability to adapt to perform, and develop unfamiliar methods in a rapidly evolving research environment

• Verbal and written proficiency in English (i.e., an excellent communicator)

• Ability to work effectively in a multi-disciplinary team and to communicate with colleagues at all levels

• Experience with the safe handling of radioactive and potentially biohazardous materials

Fusion Pharmaceuticals is an equal opportunity employer that is committed to inclusive, barrier-free recruitment and selection processes, if contacted for an interview, please advise Human Resources if you require accommodation.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.